ICD-10 Code D57.42 – Sickle-cell thalassemia beta zero without crisis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.42 – Sickle-cell thalassemia beta zero without crisis
What it is
This code identifies sickle-cell thalassemia with beta-zero thalassemia, meaning the patient has both sickle cell disease and absent beta-globin production. “Without crisis” indicates the encounter is not for an acute painful or vaso-occlusive episode.
Clinical signs
Clinical features vary; refer to documentation. Common findings in sickle-cell thalassemia include chronic hemolytic anemia, fatigue, jaundice, and a history of recurrent sickling complications.
When to use this code
Use D57.42 when the record specifically documents sickle-cell thalassemia beta zero and states there is no crisis at the time of the encounter. Apply it for routine follow-up, chronic disease management, or evaluation of stable disease. If the note does not clearly distinguish beta-zero status, check documentation.
Do not use for
Do not use this code for sickle-cell crisis, since “without crisis” excludes an acute episode. Also avoid it when the diagnosis is another sickle-cell disorder or when beta-zero thalassemia is not documented.
Coding tip
Verify both the sickle-cell thalassemia subtype and the absence of crisis in the provider note before assigning D57.42.