ICD-10 Code D57.419 – Sickle-cell thalassemia, unspecified, with crisis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.419 – Sickle-cell thalassemia, unspecified, with crisis
What it is
This code identifies sickle-cell thalassemia when the subtype is not further specified and the patient is having a crisis. It reflects a combined inherited hemoglobin disorder with an acute sickling episode.
Clinical signs
Clinical features vary; refer to documentation. Typical crisis findings may include acute pain, anemia-related symptoms, and other signs of vaso-occlusive or hemolytic episodes in a patient with sickle-cell thalassemia.
When to use this code
Use this code when the record states sickle-cell thalassemia, unspecified, and also documents a current crisis. It fits inpatient or emergency encounters where the provider links the acute episode to the underlying disorder. If the type of crisis is not specified, this code may still apply.
Do not use for
Do not use this code if the chart identifies a different sickle-cell thalassemia subtype or if no crisis is documented. Check documentation when the encounter describes a sickle-cell condition without an acute episode.
Coding tip
Confirm both elements in the note: unspecified sickle-cell thalassemia and an active crisis.