ICD-10 Code D57.3 – Sickle-cell trait (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.3 – Sickle-cell trait
What it is
D57.3 identifies sickle-cell trait, meaning the person carries one sickle hemoglobin gene but usually does not have sickle-cell disease. It is typically an inherited carrier state rather than an active hemoglobinopathy.
Clinical signs
Most patients are asymptomatic, and clinical features vary; refer to documentation. When noted, records may mention carrier status found on screening or hemoglobin testing, rather than ongoing symptoms.
When to use this code
Use D57.3 when the provider documents sickle-cell trait, sickle-cell carrier state, or a positive hemoglobin study consistent with trait. It is appropriate for routine screening follow-up, genetic counseling documentation, or problem-list coding when the trait is confirmed. Do not assume sickle-cell disease.
Do not use for
Do not use this code for sickle-cell disease, sickle-cell anemia, or other symptomatic sickling disorders. If the record is unclear, check documentation before assigning a more specific hemoglobinopathy code.
Coding tip
Code D57.3 only when the chart clearly states trait or carrier status, not merely family history or suspicion.