ICD-10 Code D57.4 – Sickle-cell thalassemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.4 – Sickle-cell thalassemia
What it is
D57.4 identifies sickle-cell thalassemia, an inherited hemoglobin disorder combining sickle cell disease with thalassemia. Use it when the record documents this specific mixed condition.
Clinical signs
Clinical features vary; refer to documentation. Typical findings may include chronic hemolytic anemia, episodes of pain, and other complications seen in sickling disorders.
When to use this code
Use this code when the provider states sickle-cell thalassemia, sickle beta-thalassemia, or a clearly documented equivalent diagnosis. It may appear in problem lists, discharge summaries, or coded assessments. Check documentation if the record only says sickle cell disease or thalassemia separately.
Do not use for
Do not use D57.4 for uncomplicated sickle-cell trait or for thalassemia without sickling. If the diagnosis is unclear or incomplete, check documentation.
Coding tip
Code only when the mixed diagnosis is explicitly documented; otherwise, query for the exact hemoglobin disorder.