ICD-10 Code D57.219 – Sickle-cell/Hb-C disease with crisis, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.219 – Sickle-cell/Hb-C disease with crisis, unspecified
What it is
D57.219 identifies sickle-cell/Hb-C disease when the patient is having a crisis, but the specific crisis type is not documented. Use it for the compound heterozygous hemoglobinopathy involving sickle hemoglobin and hemoglobin C.
Clinical signs
Clinical features vary; refer to documentation. Typical crises may include acute pain, anemia-related symptoms, or other sickling complications, but you should only code what is recorded in the chart.
When to use this code
Use this code when the provider documents sickle-cell/Hb-C disease and a crisis, but does not specify whether it is vaso-occlusive, aplastic, splenic sequestration, or another type. It also fits when the record clearly supports crisis but lacks further detail. Check documentation if the hemoglobinopathy is described differently.
Do not use for
Do not use this code for sickle-cell disease without Hb-C involvement, or for Hb-C trait alone. If the chart specifies a different sickle-cell crisis type, code that more specific option instead.
Coding tip
Look for both the Hb-C diagnosis and the crisis wording in the same encounter note before assigning D57.219.