ICD-10 Code D59.4 – Other nonautoimmune hemolytic anemias (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D59.4 – Other nonautoimmune hemolytic anemias
What it is
D59.4 identifies hemolytic anemias caused by red blood cell destruction that is not due to an autoimmune process. Use it for documented nonautoimmune hemolysis when the record does not fit a more specific hemolytic anemia code.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include anemia with evidence of hemolysis, such as jaundice, dark urine, fatigue, or splenomegaly, when the cause is not autoimmune.
When to use this code
Use this code when the provider documents a nonautoimmune hemolytic anemia and does not name a more specific etiology. It is appropriate for cases where hemolysis is confirmed but the mechanism is not otherwise classified. Check documentation if the chart suggests an inherited, drug-induced, or mechanical cause.
Do not use for
Do not use D59.4 for autoimmune hemolytic anemia or for hemolysis with a clearly identified specific cause that has its own code. If the record is unclear, check documentation rather than assuming this category.
Coding tip
Code the most specific hemolytic anemia documented, and verify whether the cause is nonautoimmune before assigning D59.4.