ICD-10 Code D59.3 – Hemolytic-uremic syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D59.3 – Hemolytic-uremic syndrome
What it is
D59.3 identifies hemolytic-uremic syndrome, a condition marked by destruction of red blood cells, low platelets, and kidney injury. It is a serious microangiopathic disorder that requires careful clinical documentation.
Clinical signs
Typical findings include anemia from hemolysis, thrombocytopenia, and evidence of renal impairment. Clinical features vary; refer to documentation, especially when the record distinguishes typical, atypical, or secondary forms.
When to use this code
Use D59.3 when the provider documents hemolytic-uremic syndrome as the diagnosis, including cases with kidney involvement and hemolysis. Apply it when the record clearly supports HUS rather than another thrombotic microangiopathy. If the note only says hemolytic anemia or acute kidney injury, check documentation before assigning this code.
Do not use for
Do not use D59.3 for isolated hemolytic anemia, thrombocytopenia, or renal failure without documented hemolytic-uremic syndrome. Check documentation if the condition is described as thrombotic thrombocytopenic purpura or another microangiopathic process.
Coding tip
Code D59.3 only when HUS is explicitly documented; if the etiology or subtype is unclear, query the provider.