ICD-10 Code D82.9 – Immunodeficiency associated with major defect, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D82.9 – Immunodeficiency associated with major defect, unspecified
What it is
D82.9 identifies an immunodeficiency linked to a major defect, but the specific defect is not named in the record. Use it when documentation confirms this type of immune disorder without further detail.
Clinical signs
Clinical features vary; refer to documentation. Commonly, records may describe recurrent or unusual infections, poor immune response, or a known congenital immune defect.
When to use this code
Use this code when the provider documents immunodeficiency associated with a major defect and does not specify the exact syndrome or defect. It also fits when the chart notes a major immune abnormality but leaves the condition unspecified.
If the documentation names a more specific immunodeficiency, code that diagnosis instead. Check the full record for the underlying defect, associated syndrome, or any clarified etiology.
Do not use for
Do not use D82.9 for common, nonspecific immune weakness or for immunodeficiency due to medications or infection. Check documentation if the condition is better described by another specific ICD-10 code.
Coding tip
Code D82.9 only when the chart supports a major-defect immunodeficiency and the provider has not identified a more specific diagnosis.