ICD-10 Code D57.459 – Sickle-cell thalassemia beta plus with crisis, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.459 – Sickle-cell thalassemia beta plus with crisis, unspecified
What it is
D57.459 identifies sickle-cell thalassemia beta-plus with an unspecified crisis. Use it when the record shows this inherited hemoglobin disorder and a sickle-cell crisis, but the crisis type is not documented.
Clinical signs
Typical findings include anemia-related symptoms and painful vaso-occlusive episodes. Clinical features vary; refer to documentation for the specific crisis presentation and any associated complications.
When to use this code
Use this code when the clinician documents beta-plus sickle-cell thalassemia and states there is a crisis, but does not specify the crisis type. It also fits encounters for evaluation or management of the crisis when the diagnosis is clearly recorded. Check documentation if the note only says sickle-cell disease without thalassemia subtype.
Do not use for
Do not use this code for sickle-cell thalassemia without crisis, or when the record specifies a different sickle-cell crisis code. Check documentation if the subtype is unclear or the condition is described only as thalassemia trait.
Coding tip
Confirm both the beta-plus thalassemia subtype and the presence of crisis before assigning D57.459.