ICD-10 Code D57.433 – Sickle-cell thalassemia beta zero with cerebral vascular involvement (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.433 – Sickle-cell thalassemia beta zero with cerebral vascular involvement
What it is
This code identifies sickle-cell beta zero thalassemia with a documented cerebral vascular complication. Use it when the record shows both the hemoglobin disorder and involvement of the brain’s blood vessels.
Clinical signs
Clinical features vary; refer to documentation. Records may describe sickle-cell disease manifestations along with cerebrovascular disease, such as stroke, transient ischemic attack, or other cerebral vascular involvement.
When to use this code
Use this code when the provider documents sickle-cell thalassemia beta zero and specifically links it to cerebral vascular involvement. It is appropriate for encounters focused on prior or current cerebrovascular complications in this setting.
Check documentation if the note only says sickle-cell crisis, stroke history, or thalassemia without the beta zero subtype. The code should reflect the exact stated diagnosis, not an assumed complication.
Do not use for
Do not use this code for other sickle-cell genotypes, uncomplicated sickle-cell thalassemia, or cerebrovascular disease without the beta zero thalassemia link. Check documentation when the subtype is unclear.
Coding tip
Verify that both the beta zero subtype and cerebral vascular involvement are explicitly documented before assigning D57.433.