ICD-10 Code D57.432 – Sickle-cell thalassemia beta zero with splenic sequestration (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.432 – Sickle-cell thalassemia beta zero with splenic sequestration
What it is
This code identifies sickle-cell thalassemia beta zero with an episode of splenic sequestration. It describes a sickling disorder with absent beta-globin production and acute trapping of blood in the spleen.
Clinical signs
Clinical features vary; refer to documentation. Typical findings include sudden splenic enlargement, abdominal pain, pallor, and signs of acute anemia in a patient with sickle-cell thalassemia.
When to use this code
Use this code when the record clearly documents sickle-cell thalassemia beta zero and splenic sequestration together. It is appropriate for an acute sequestration event in a patient whose hemoglobinopathy type is specified. If the subtype or sequestration is not stated, check documentation before assigning D57.432.
Do not use for
Do not use this code for sickle-cell disease without thalassemia, or for thalassemia without a documented sickling disorder. Do not assign it when splenic sequestration is absent or not documented.
Coding tip
Confirm both the hemoglobinopathy subtype and the sequestration episode in the provider note before coding.