ICD-10 Code D57.413 – Sickle-cell thalassemia, unspecified, with cerebral vascular involvement (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.413 – Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
What it is
This code identifies sickle-cell thalassemia, unspecified type, when there is cerebral vascular involvement. Use it for a documented sickling disorder affecting the brain’s blood vessels, such as stroke or related cerebrovascular disease.
Clinical signs
Clinical features vary; refer to documentation. Commonly recorded findings include neurologic deficits, speech changes, weakness, altered mental status, or imaging evidence of cerebral vascular disease in a patient with sickle-cell thalassemia.
When to use this code
Use this code when the provider documents sickle-cell thalassemia and a cerebral vascular complication, and the type is not further specified. It applies when the record links the cerebrovascular condition to the sickling disorder. If the cerebrovascular involvement is not documented, check documentation before coding.
Do not use for
Do not use this code for sickle-cell thalassemia without cerebral vascular involvement, or for cerebrovascular disease unrelated to the hemoglobin disorder. If the thalassemia subtype is specified differently, use the more specific code.
Coding tip
Verify that the chart explicitly connects the cerebral vascular event to sickle-cell thalassemia before assigning D57.413.