ICD-10 Code D57.213 – Sickle-cell/Hb-C disease with cerebral vascular involvement (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.213 – Sickle-cell/Hb-C disease with cerebral vascular involvement
What it is
D57.213 identifies sickle-cell/Hb-C disease complicated by cerebral vascular involvement. Use it when the record shows this hemoglobinopathy and a cerebrovascular complication, such as stroke or related brain vessel disease.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include neurologic deficits, speech changes, weakness, altered mental status, or imaging evidence of cerebral vascular injury in a patient with sickle-cell/Hb-C disease.
When to use this code
Use this code when the provider documents sickle-cell/Hb-C disease and specifies cerebral vascular involvement. It is appropriate for encounters describing prior or current cerebrovascular complications linked to the disorder. If the record only states sickle-cell disease without cerebral involvement, choose a different code.
Do not use for
Do not use this code for uncomplicated sickle-cell/Hb-C disease or for cerebrovascular disease without a documented sickle-cell/Hb-C link. Check documentation if the neurologic event is not clearly attributed to this condition.
Coding tip
Confirm both the hemoglobinopathy type and the cerebral vascular complication in the provider note before assigning D57.213.