ICD-10 Code D57.418 – Sickle-cell thalassemia, unspecified, with crisis with other specified complication (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.418 – Sickle-cell thalassemia, unspecified, with crisis with other specified complication
What it is
This code identifies sickle-cell thalassemia, a compound hemoglobin disorder, when the patient is in crisis and has another specified complication. Use it when documentation names the crisis and the additional complication, but does not specify the thalassemia type.
Clinical signs
Clinical features vary; refer to documentation. Crisis may present with acute pain, anemia-related symptoms, or other sickle-cell complications, along with a documented additional complication such as acute chest syndrome or splenic issues.
When to use this code
Use this code when the record clearly states sickle-cell thalassemia, unspecified, with a crisis and another specified complication. It is appropriate for inpatient or outpatient encounters where the provider links the crisis to the complication. If the subtype is documented, choose the more specific code instead.
Do not use for
Do not use this code for sickle-cell disease without thalassemia, or for thalassemia without a sickle-cell crisis. If the complication is not specified, check documentation.
Coding tip
Confirm both the crisis and the named complication in the provider note before assigning D57.418.