ICD-10 Code D57.411 – Sickle-cell thalassemia, unspecified, with acute chest syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.411 – Sickle-cell thalassemia, unspecified, with acute chest syndrome
What it is
This code identifies sickle-cell thalassemia when the type is not further specified and the patient has acute chest syndrome. It combines an inherited hemoglobin disorder with a serious pulmonary complication.
Clinical signs
Typical findings include chest pain, cough, fever, shortness of breath, or new pulmonary infiltrates in a patient with sickle-cell disease. Clinical features vary; refer to documentation.
When to use this code
Use this code when the record clearly documents sickle-cell thalassemia, unspecified, and acute chest syndrome is present during the encounter. Code it for inpatient or outpatient visits when the provider links the chest syndrome to the sickle-cell disorder.
If the chart names a more specific sickle-cell thalassemia type, use the documented code instead. Check documentation when the chest findings are described without an explicit acute chest syndrome diagnosis.
Do not use for
Do not use this code for uncomplicated sickle-cell thalassemia without acute chest syndrome. Also avoid it when the provider documents another sickle-cell variant or a different respiratory diagnosis.
Coding tip
Confirm both the unspecified sickle-cell thalassemia diagnosis and the acute chest syndrome association in the provider note before assigning D57.411.