ICD-10 Code D57.41 – Sickle-cell thalassemia, unspecified, with crisis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.41 – Sickle-cell thalassemia, unspecified, with crisis
What it is
This code identifies sickle-cell thalassemia when the type is not further specified and the patient is having a crisis. It reflects a combined hemoglobin disorder with an acute sickling episode.
Clinical signs
Clinical features vary; refer to documentation. Commonly, you may see pain crisis, anemia-related findings, or other acute sickle-cell complications noted by the clinician.
When to use this code
Use this code when the record states sickle-cell thalassemia, unspecified, and documents a crisis or acute exacerbation. It fits inpatient or outpatient encounters where the crisis is the active reason for care. If the type or crisis status is unclear, check documentation.
Do not use for
Do not use this code for sickle-cell thalassemia without crisis, or when a more specific sickle-cell thalassemia subtype is documented. Do not apply it to other sickle-cell disorders or thalassemia alone.
Coding tip
Verify both elements in the note: unspecified sickle-cell thalassemia and current crisis, before assigning D57.41.