ICD-10 Code D57.40 – Sickle-cell thalassemia without crisis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.40 – Sickle-cell thalassemia without crisis
What it is
D57.40 identifies sickle-cell thalassemia when the patient is not having an acute sickle crisis. It combines sickle cell disease with thalassemia and is used for the stable, non-crisis condition.
Clinical signs
Clinical features vary; refer to documentation. You may see chronic anemia, fatigue, jaundice, or splenomegaly, but the record should support sickle-cell thalassemia and note the absence of crisis.
When to use this code
Use D57.40 when the provider documents sickle-cell thalassemia and explicitly states there is no crisis. It also fits routine follow-up visits, stable chronic management, or evaluation of baseline disease without an acute painful episode. Check documentation if the note is unclear.
Do not use for
Do not use this code for a current sickle crisis, such as vaso-occlusive pain or acute chest syndrome. Do not assign it if the record only says sickle-cell disease or thalassemia without specifying the combined diagnosis.
Coding tip
Confirm both components—sickle-cell disease and thalassemia—and look for wording such as “without crisis” before assigning D57.40.