ICD-10 Code D57.212 – Sickle-cell/Hb-C disease with splenic sequestration (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.212 – Sickle-cell/Hb-C disease with splenic sequestration
What it is
D57.212 identifies sickle-cell/Hb-C disease complicated by splenic sequestration. Use it when the record shows this hemoglobinopathy and the spleen is trapping blood cells, causing acute enlargement or anemia.
Clinical signs
Typical documentation includes sickle-cell/Hb-C disease with sudden splenomegaly, pallor, abdominal pain, or worsening anemia. Clinical features vary; refer to documentation.
When to use this code
Use this code when the provider documents Hb-C sickle-cell disease and specifically notes splenic sequestration. It is appropriate for an acute sequestration episode or when the condition is clearly listed as an active diagnosis. If the chart only says sickle-cell disease without the Hb-C type or sequestration, check documentation.
Do not use for
Do not use it for uncomplicated sickle-cell/Hb-C disease or for splenic enlargement without sequestration. Do not assume the diagnosis from suspected symptoms alone.
Coding tip
Verify both elements in the note: the Hb-C sickle-cell type and the splenic sequestration complication.