ICD-10 Code D57.453 – Sickle-cell thalassemia beta plus with cerebral vascular involvement (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.453 – Sickle-cell thalassemia beta plus with cerebral vascular involvement
What it is
This code identifies sickle-cell beta-plus thalassemia with documented cerebral vascular involvement. Use it when the record shows a sickling disorder affecting cerebral blood vessels or a cerebrovascular complication linked to the condition.
Clinical signs
Clinical features vary; refer to documentation. You may see evidence of sickle-cell disease with neurologic or cerebrovascular involvement, such as prior stroke, transient ischemic symptoms, or other recorded cerebral vascular findings.
When to use this code
Use this code when the provider documents sickle-cell thalassemia beta plus and specifically links it to cerebral vascular involvement. It is appropriate for encounters focused on a cerebrovascular complication in the setting of this hemoglobinopathy. If the note does not clearly connect the two, check documentation before coding.
Do not use for
Do not use this code for sickle-cell beta-plus thalassemia without cerebral vascular involvement. Also avoid it when the chart only mentions a history of stroke or a nonspecific cerebrovascular disorder without the documented sickle-cell linkage.
Coding tip
Confirm both the hemoglobinopathy type and the cerebral vascular involvement are explicitly documented before assigning D57.453.