ICD-10 Code D57.458 – Sickle-cell thalassemia beta plus with crisis with other specified complication (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.458 – Sickle-cell thalassemia beta plus with crisis with other specified complication
What it is
This code identifies sickle-cell thalassemia beta plus with a current sickle-cell crisis and another specified complication. Use it when the record shows both the hemoglobin disorder and the crisis, plus an additional documented complication.
Clinical signs
Clinical features vary; refer to documentation. Typical crisis findings may include acute pain and other signs of sickling, while the extra complication must be clearly named in the record.
When to use this code
Use this code when the provider documents sickle-cell thalassemia beta plus and states the patient is in crisis. You also need a specific “other specified complication” linked to the encounter. If the complication is not named, check documentation before coding.
Do not use for
Do not use this code if the record does not confirm crisis or if the complication is unspecified. Do not substitute it for other sickle-cell disorders, thalassemia without sickling, or a history of crisis only.
Coding tip
Verify that both the crisis and the additional complication are explicitly documented before assigning D57.458.