ICD-10 Code D57.454 – Sickle-cell thalassemia beta plus with dactylitis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.454 – Sickle-cell thalassemia beta plus with dactylitis
What it is
D57.454 identifies sickle-cell thalassemia, beta-plus type, when dactylitis is documented. It combines a sickling hemoglobin disorder with thalassemia and a painful swelling of the hands or feet.
Clinical signs
Look for a documented sickle-cell thalassemia beta-plus disorder plus dactylitis, especially painful swelling of the digits in an infant or child. Clinical features vary; refer to documentation.
When to use this code
Use this code when the provider specifically documents sickle-cell thalassemia beta plus and notes dactylitis. It is appropriate for encounters addressing the acute digit swelling as part of the confirmed hemoglobinopathy. If the record says only sickle-cell disease, check documentation for the exact subtype.
Do not use for
Do not use this code if dactylitis is absent or if the record identifies another sickle-cell genotype. Check documentation when the note only says sickle-cell anemia, thalassemia trait, or hand-foot syndrome without the combined diagnosis.
Coding tip
Assign D57.454 only when both beta-plus thalassemia and dactylitis are clearly documented together.