ICD-10 Code D57.452 – Sickle-cell thalassemia beta plus with splenic sequestration (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.452 – Sickle-cell thalassemia beta plus with splenic sequestration
What it is
This code identifies sickle-cell thalassemia beta plus with an episode of splenic sequestration. Use it when the record shows a sickling disorder combined with beta-plus thalassemia and the spleen is trapping blood cells.
Clinical signs
Clinical features vary; refer to documentation. Typical findings may include an enlarged, painful spleen, sudden anemia, pallor, weakness, and abdominal discomfort in a patient with sickle-cell thalassemia.
When to use this code
Use this code when the provider documents sickle-cell thalassemia beta plus and specifically notes splenic sequestration. It is appropriate for an acute sequestration episode or a documented history of the condition when coding the encounter. Check documentation if the genotype or sequestration status is unclear.
Do not use for
Do not use this code for other sickle-cell disorders, thalassemia without sickling, or splenomegaly alone. If the chart does not confirm beta-plus thalassemia and splenic sequestration together, check documentation.
Coding tip
Verify both the hemoglobinopathy subtype and the splenic sequestration diagnosis in the provider note before assigning D57.452.