ICD-10 Code D57.43 – Sickle-cell thalassemia beta zero with crisis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.43 – Sickle-cell thalassemia beta zero with crisis
What it is
This code identifies sickle-cell thalassemia beta-zero disease when the patient is having a crisis. It combines sickling and absent beta-globin production, so you should use it only when both parts are documented.
Clinical signs
Clinical features vary; refer to documentation. Crisis may present with acute pain, anemia-related symptoms, or other sickle-cell complications, and the record should support the beta-zero thalassemia subtype.
When to use this code
Use this code when the provider documents sickle-cell thalassemia beta-zero and states that a crisis is present. It fits encounters for vaso-occlusive or other sickle-cell crises tied to this specific genotype. If the subtype or crisis is unclear, check documentation before coding.
Do not use for
Do not use it for sickle-cell trait, other sickle-cell syndromes, or thalassemia without sickling. Also avoid it when the chart does not confirm a crisis or does not specify beta-zero disease.
Coding tip
Verify both the sickle-cell crisis and the beta-zero thalassemia subtype in the provider note before assigning D57.43.