ICD-10 Code D57.412 – Sickle-cell thalassemia, unspecified, with splenic sequestration (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.412 – Sickle-cell thalassemia, unspecified, with splenic sequestration
What it is
This code identifies sickle-cell thalassemia, unspecified type, when the patient also has splenic sequestration. It signals an acute complication in which the spleen traps blood cells and enlarges.
Clinical signs
Typical findings include sudden splenic enlargement, abdominal pain, pallor, and worsening anemia. Clinical features vary; refer to documentation for the confirmed sickle-cell thalassemia type and evidence of sequestration.
When to use this code
Use this code when the record documents sickle-cell thalassemia and splenic sequestration together. It is appropriate for encounters focused on the acute sequestration episode, including emergency or inpatient care. You should confirm that the provider links the complication to the hemoglobinopathy.
Do not use for
Do not use it for sickle-cell disease without thalassemia, or for splenomegaly without sequestration. Check documentation if the thalassemia type or the acute splenic complication is not clearly stated.
Coding tip
Assign the code only when both the underlying sickle-cell thalassemia and splenic sequestration are documented in the same encounter.