ICD-10 Code F19.221 – Other Psychoactive Substance Dependence with Intoxication Delirium (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F19.221 – Other psychoactive substance dependence with intoxication delirium
What it is
This code identifies dependence on another psychoactive substance, along with delirium caused by intoxication. Use it when the record links the delirium to current substance intoxication and the substance is not separately classified.
Clinical signs
Clinical features vary; refer to documentation. Delirium commonly includes disturbed attention, confusion, altered awareness, and fluctuating thinking or behavior during intoxication.
When to use this code
Use this code when the provider documents both substance dependence and intoxication delirium from an unspecified psychoactive substance. It is appropriate when the substance is not named in a more specific ICD-10 category. You should code the documented condition exactly as recorded.
Do not use for
Do not use this code if delirium is not linked to intoxication or if the substance is better classified elsewhere. Check documentation when the record describes abuse, use, withdrawal, or an intoxication state without delirium.
Coding tip
Verify that dependence and intoxication delirium are both documented before assigning F19.221.