ICD-10 Code C85.22 – Mediastinal (thymic) large B-cell lymphoma, intrathoracic lymph nodes (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C85.22 – Mediastinal (thymic) large B-cell lymphoma, intrathoracic lymph nodes
What it is
C85.22 identifies a specific large B-cell lymphoma arising in the mediastinum, often near the thymus, with involvement of intrathoracic lymph nodes. Use it when the record clearly documents this lymphoma subtype and nodal location.
Clinical signs
Clinical features vary; refer to documentation. Patients may present with a mediastinal mass, chest symptoms, or enlarged intrathoracic lymph nodes confirmed by pathology or imaging.
When to use this code
Use this code when the provider documents mediastinal (thymic) large B-cell lymphoma and specifies intrathoracic lymph node involvement. It is appropriate for confirmed diagnoses, staging records, and oncology encounters tied to this exact lymphoma type. Check documentation if the site or histology is unclear.
Do not use for
Do not use this code for nonspecific lymphoma, other diffuse large B-cell lymphomas, or mediastinal masses without confirmed lymphoma. If the record does not specify intrathoracic lymph nodes, check documentation.
Coding tip
Verify both the lymphoma subtype and the anatomic site before assigning C85.22.