ICD-10 Code E85.9 – Amyloidosis, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E85.9 – Amyloidosis, unspecified
What it is
This code identifies amyloidosis when the record does not specify the type or organ involvement. Amyloidosis is a disorder in which abnormal protein deposits build up in tissues.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings may include unexplained organ dysfunction, enlargement of affected organs, or signs related to heart, kidney, nerve, or gastrointestinal involvement.
When to use this code
Use E85.9 when the clinician documents amyloidosis but does not identify a specific subtype, such as AL or hereditary forms. It also fits when the chart confirms amyloid disease yet gives no clear organ designation. If a more specific code is available, you should code that instead.
Do not use for
Do not use this code for a documented amyloidosis subtype or for isolated organ manifestations without confirmed amyloid disease. Check documentation if the note only suggests amyloidosis or uses a rule-out diagnosis.
Coding tip
Query for the amyloid type and involved organ when the note is vague, because a more specific code may better reflect the record.