ICD-10 Code E85.82 – Wild-type transthyretin-related (ATTR) amyloidosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E85.82 – Wild-type transthyretin-related (ATTR) amyloidosis
What it is
This code identifies wild-type transthyretin amyloidosis, a condition caused by normal transthyretin proteins misfolding and forming amyloid deposits. It usually affects older adults and commonly involves the heart.
Clinical signs
Clinical features vary; refer to documentation. Common findings include restrictive cardiomyopathy, heart failure symptoms, arrhythmias, and possible carpal tunnel syndrome or neuropathic complaints.
When to use this code
Use E85.82 when the provider documents wild-type ATTR amyloidosis, senile systemic amyloidosis, or ATTR cardiac amyloidosis due to wild-type transthyretin. Code it when the diagnosis is confirmed or clearly established in the record. Check documentation if the note only says “amyloidosis” or “ATTR” without type.
Do not use for
Do not use this code for hereditary or variant transthyretin amyloidosis, other amyloidosis types, or unspecified amyloidosis. If the subtype is unclear, check documentation before assigning E85.82.
Coding tip
Look for the words “wild-type,” “senile,” or “nonhereditary” in the provider’s diagnosis to support this code.