ICD-10 Code E85.1 – Neuropathic heredofamilial amyloidosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E85.1 – Neuropathic heredofamilial amyloidosis
What it is
This code identifies hereditary amyloidosis with predominant nerve involvement. It is used when amyloid protein deposits are documented as causing a familial neuropathic disorder.
Clinical signs
Clinical features vary; refer to documentation. Common findings include peripheral neuropathy, sensory loss, autonomic dysfunction, and progressive weakness in a patient with a hereditary amyloidosis diagnosis.
When to use this code
Use E85.1 when the record clearly states neuropathic heredofamilial amyloidosis or a hereditary amyloidosis affecting the nervous system. It fits confirmed family history and documented amyloid-related neuropathy. Check documentation if the type is not specified.
Do not use for
Do not use this code for nonhereditary amyloidosis, unspecified amyloidosis, or neuropathy without documented amyloid disease. If the subtype is unclear, code the documented condition only.
Coding tip
Confirm that the provider links neuropathy to hereditary amyloidosis before assigning E85.1.