ICD-10 Code E85 – Amyloidosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E85 – Amyloidosis
What it is
Amyloidosis is a group of disorders in which abnormal amyloid proteins build up in tissues and organs. Use E85 when the record documents amyloidosis without a more specific subtype.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include organ dysfunction involving the heart, kidneys, liver, nerves, or gastrointestinal tract, but the specific pattern depends on the amyloid type.
When to use this code
Use this code when the provider diagnoses amyloidosis and does not document a more specific category. It also fits when the chart confirms amyloid deposition affecting one or more organs, but the subtype is not identified. Check documentation if the record names a specific amyloidosis type.
Do not use for
Do not use E85 if the documentation specifies a more detailed amyloidosis code. Do not assign it for suspected amyloidosis, family history, or nonspecific protein abnormalities without a confirmed diagnosis.
Coding tip
Look for the exact amyloidosis subtype in the assessment, pathology, or problem list before defaulting to E85.