ICD-10 Code D59.31 – Infection-associated hemolytic-uremic syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D59.31 – Infection-associated hemolytic-uremic syndrome
What it is
D59.31 identifies hemolytic-uremic syndrome triggered by an infection. Use it when the record shows this specific infection-associated form of thrombotic microangiopathy.
Clinical signs
Clinical features vary; refer to documentation. Commonly, records describe hemolytic anemia, low platelet count, and acute kidney injury after an infectious illness.
When to use this code
Use D59.31 when the provider documents infection-associated hemolytic-uremic syndrome, including postinfectious HUS or infection-triggered HUS. It is appropriate when the note clearly links the syndrome to an infection rather than another cause. Check documentation if the trigger is not stated.
Do not use for
Do not use this code for hemolytic-uremic syndrome without an infectious cause, or for thrombotic thrombocytopenic purpura. If the chart only says “HUS” and does not identify infection, check documentation.
Coding tip
Confirm the causal infection is documented, because D59.31 is assigned only when the link to infection is explicit.