ICD-10 Code D59.12 – Cold autoimmune hemolytic anemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D59.12 – Cold autoimmune hemolytic anemia
What it is
Cold autoimmune hemolytic anemia is an acquired anemia caused by antibodies that react at lower temperatures and destroy red blood cells. Use this code when documentation identifies cold autoimmune hemolysis or cold agglutinin disease.
Clinical signs
Typical findings include anemia with hemolysis and symptoms that may worsen with cold exposure. Clinical features vary; refer to documentation for evidence of cold-reactive antibodies or hemolytic anemia.
When to use this code
Use D59.12 when the provider documents cold autoimmune hemolytic anemia, cold agglutinin disease, or cold antibody-mediated hemolysis. Code it for confirmed diagnoses in outpatient, inpatient, or problem-list documentation. If the record only says anemia or hemolysis without an autoimmune cold cause, check documentation.
Do not use for
Do not use this code for other hemolytic anemias, anemia of chronic disease, or unspecified anemia. If the chart does not clearly identify a cold autoimmune cause, do not assume it.
Coding tip
Look for the exact provider wording “cold autoimmune hemolytic anemia” or “cold agglutinin disease” before assigning D59.12.