ICD-10 Code D59.0 – Drug-induced autoimmune hemolytic anemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D59.0 – Drug-induced autoimmune hemolytic anemia
What it is
D59.0 identifies autoimmune hemolytic anemia caused by a medication. The immune system destroys red blood cells after drug exposure, leading to anemia.
Clinical signs
Clinical features vary; refer to documentation. Common findings include anemia symptoms, jaundice, dark urine, and evidence of hemolysis after a drug is started.
When to use this code
Use D59.0 when the provider documents drug-induced autoimmune hemolytic anemia or clearly links hemolysis to a medication. Code the diagnosis even if the offending drug is also listed separately.
Apply this code when the record supports an immune-mediated hemolytic process rather than a nonspecific anemia. Check documentation if the cause is uncertain or if hemolysis is attributed to another condition.
Do not use for
Do not use D59.0 for anemia without documented hemolysis or for hemolytic anemia from non-drug causes. Check documentation if the record only states “drug-related anemia.”
Coding tip
Confirm the provider’s causal language; D59.0 requires a documented drug trigger, not just anemia during medication use.