ICD-10 Code D57.45 – Sickle-cell thalassemia beta plus with crisis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.45 – Sickle-cell thalassemia beta plus with crisis
What it is
This code identifies sickle-cell beta-plus thalassemia when the patient is in a sickling crisis. It combines a hemoglobinopathy with an acute painful or vaso-occlusive episode.
Clinical signs
Clinical features vary; refer to documentation. Common crisis findings include acute pain, swelling, fatigue, or other signs of vaso-occlusion in a patient with confirmed sickle-cell beta-plus thalassemia.
When to use this code
Use this code when the record documents sickle-cell beta-plus thalassemia and a current crisis, such as a painful crisis or vaso-occlusive episode. Code it only when the provider links the crisis to this specific hemoglobinopathy. Check documentation if the type of crisis is unclear.
Do not use for
Do not use this code for sickle-cell trait, other sickle-cell disorders without beta-plus thalassemia, or thalassemia without crisis. Do not assume a crisis from chronic anemia alone.
Coding tip
Confirm both the beta-plus thalassemia diagnosis and the active crisis in the note before assigning D57.45.