ICD-10 Code D57.439 – Sickle-cell thalassemia beta zero with crisis, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.439 – Sickle-cell thalassemia beta zero with crisis, unspecified
What it is
This code identifies sickle-cell thalassemia beta zero with an acute crisis, but the specific crisis type is not documented. It applies when the record confirms this inherited hemoglobin disorder and a current sickling episode.
Clinical signs
Clinical features vary; refer to documentation. Common crisis findings include acute pain, anemia-related symptoms, and other signs of vaso-occlusion or hemolysis consistent with a sickle-cell event.
When to use this code
Use D57.439 when the clinician documents sickle-cell thalassemia beta zero and states that the patient is in crisis, but does not specify the crisis type. You may use it for emergency, inpatient, or outpatient encounters if the active crisis is clearly documented.
Do not use for
Do not use this code if the record only says sickle-cell thalassemia without crisis, or if a different crisis type is named. Check documentation when the genotype or crisis status is unclear.
Coding tip
Code the exact crisis wording first; if the type is unspecified, D57.439 is appropriate.