ICD-10 Code D57.438 – Sickle-cell thalassemia beta zero with crisis with other specified complication (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.438 – Sickle-cell thalassemia beta zero with crisis with other specified complication
What it is
This code identifies sickle-cell beta zero thalassemia with a documented crisis and another specified complication. Use it when the record clearly links the hemoglobin disorder, the crisis, and the additional complication.
Clinical signs
Clinical features vary; refer to documentation. Typical sickle-cell crises may include acute pain, anemia-related findings, or other organ-related complications described by the clinician.
When to use this code
Use D57.438 when the provider documents sickle-cell beta zero thalassemia, a crisis, and a named complication that is not otherwise classified. The chart should support all parts of the description. If the complication is not specified, check documentation before coding.
Do not use for
Do not use this code for sickle-cell disorders without beta zero thalassemia, or when no crisis is documented. It is also incorrect if the complication is absent or documented elsewhere without clear linkage.
Coding tip
Confirm the exact hemoglobin subtype and the specific crisis-related complication in the provider note before assigning this code.