ICD-10 Code D57.20 – Sickle-cell/Hb-C disease without crisis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.20 – Sickle-cell/Hb-C disease without crisis
What it is
D57.20 identifies sickle-cell/Hb-C disease when the patient is not having an acute crisis. It is used for the chronic hemoglobinopathy caused by inherited sickle hemoglobin and hemoglobin C.
Clinical signs
Clinical features vary; refer to documentation. Patients may have chronic anemia, splenomegaly, fatigue, or a history of sickling-related complications, but this code does not describe an acute pain episode.
When to use this code
Use D57.20 when the record clearly documents sickle-cell/Hb-C disease and states there is no crisis. It fits routine follow-up, stable chronic disease, or encounters for ongoing management without an acute sickle-cell event. If the note mentions a crisis, select the more specific crisis code instead.
Do not use for
Do not use this code for sickle-cell trait, other sickle-cell genotypes, or an acute sickle-cell crisis. Check documentation if the provider does not specify Hb-C disease or the presence of crisis.
Coding tip
Confirm both the genotype and “without crisis” wording in the assessment before assigning D57.20.