ICD-10 Code D57.2 – Sickle-cell/Hb-C disease (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D57.2 – Sickle-cell/Hb-C disease
What it is
D57.2 identifies sickle-cell/Hb-C disease, a form of sickle cell disorder caused by inheriting hemoglobin S and hemoglobin C. You use it when the record states this specific genotype or diagnosis.
Clinical signs
Clinical features vary; refer to documentation. Commonly noted findings include chronic hemolytic anemia and sickling-related complications such as pain episodes, jaundice, or splenic problems.
When to use this code
Use D57.2 when the provider documents sickle-cell/Hb-C disease, HbSC disease, or an equivalent confirmed diagnosis. It may appear in outpatient assessments, discharge summaries, or problem lists when the condition is active or relevant to care.
If the note only says “sickle cell disease” without specifying the hemoglobin variant, check documentation before coding. Apply the code when the genotype is clearly identified and supported in the chart.
Do not use for
Do not use this code for sickle-cell trait, Hb-C trait, or unspecified sickle-cell anemia. Check documentation if the record describes another sickling disorder or does not confirm HbSC disease.
Coding tip
Confirm the exact hemoglobin combination in the provider note before assigning D57.2.