ICD-10 Code G92.00 – Immune Effector Cell-Associated Neurotoxicity Syndrome, Grade Unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code G92.00 – Immune effector cell-associated neurotoxicity syndrome, grade unspecified
What it is
G92.00 identifies immune effector cell-associated neurotoxicity syndrome when the grade is not documented. Use it for neurotoxicity linked to immune effector cell therapies, such as CAR-T, when the record confirms the syndrome but not severity.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include confusion, altered attention, expressive language problems, tremor, or seizures, but you should code only what is documented in the chart.
When to use this code
Use this code when the provider diagnoses immune effector cell-associated neurotoxicity syndrome and does not specify a grade. It is appropriate in encounters tied to recent immune effector cell therapy, especially when neurologic changes are attributed to treatment. If a grade is documented, use the more specific code instead.
Do not use for
Do not use this code for nonspecific delirium, encephalopathy, or neurologic symptoms without a documented immune effector cell-related syndrome. Check documentation if the reaction is better described by another diagnosis.
Coding tip
Look for the provider’s explicit diagnosis of immune effector cell-associated neurotoxicity syndrome and any documented grade before assigning G92.00.