ICD-10 Code D89.0 – Polyclonal hypergammaglobulinemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D89.0 – Polyclonal hypergammaglobulinemia
What it is
Polyclonal hypergammaglobulinemia means an increased amount of several types of immunoglobulins in the blood. It usually reflects broad immune system activation rather than a single abnormal clone.
Clinical signs
Clinical features vary; refer to documentation. Patients may have findings related to the underlying condition, such as chronic infection, autoimmune disease, liver disease, or inflammatory disorders.
When to use this code
Use D89.0 when the provider documents polyclonal hypergammaglobulinemia as a diagnosis, finding, or reason for evaluation. Code it when the record clearly distinguishes it from monoclonal gammopathy or other plasma cell disorders.
If it is listed as part of a workup for immune activation or chronic inflammatory disease, this code may apply. Check documentation for the stated cause and whether the hypergammaglobulinemia is confirmed.
Do not use for
Do not use this code for monoclonal gammopathy, multiple myeloma, or other specific plasma cell dyscrasias. Do not assign it when the chart only notes abnormal protein studies without confirming polyclonal hypergammaglobulinemia.
Coding tip
Confirm the word “polyclonal” in the provider note before coding D89.0, and capture any documented underlying condition separately when appropriate.