ICD-10 Code E27.3 – Drug-induced adrenocortical insufficiency (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E27.3 – Drug-induced adrenocortical insufficiency
What it is
E27.3 identifies adrenal cortex insufficiency caused by a drug or medication. Use it when documentation shows the adrenal problem is medication-related rather than due to another adrenal disease.
Clinical signs
Clinical features vary; refer to documentation. Commonly, records may describe adrenal insufficiency with fatigue, weakness, low blood pressure, or other signs of cortisol deficiency after drug exposure.
When to use this code
Use E27.3 when the provider links adrenal insufficiency to a medication, such as steroid withdrawal or another drug effect. The note should clearly state the condition is drug-induced; if not, check documentation. Code the underlying adverse drug effect when supported by the record.
Do not use for
Do not use this code for primary adrenal insufficiency, congenital adrenal disorders, or adrenal insufficiency with no medication cause documented. If the cause is unclear, check documentation.
Coding tip
Look for explicit wording such as “drug-induced” or “due to medication” before assigning E27.3.