ICD-10 Code E27.1 – Primary adrenocortical insufficiency (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E27.1 – Primary adrenocortical insufficiency
What it is
Use this code for primary adrenal cortex failure, also called Addison disease, when the adrenal glands cannot produce adequate hormones. It reflects a disorder originating in the adrenal glands, not a pituitary or hypothalamic cause.
Clinical signs
Typical findings include chronic fatigue, weight loss, low blood pressure, skin hyperpigmentation, and salt craving. Clinical features vary; refer to documentation for the specific presentation and confirmed diagnosis.
When to use this code
Assign E27.1 when the provider documents primary adrenocortical insufficiency or Addison disease as the confirmed diagnosis. Use it for outpatient visits, hospital encounters, or problem-list documentation when the condition is being evaluated or managed.
Code it when records distinguish primary adrenal failure from secondary or unspecified adrenal insufficiency. If the note only says “adrenal insufficiency” without clarification, check documentation before selecting this code.
Do not use for
Do not use E27.1 for secondary or pituitary-related adrenal insufficiency, or for nonspecific adrenal insufficiency when the cause is not documented. Check documentation if the record mentions adrenal crisis without confirming the underlying disorder.
Coding tip
Look for the word “primary” or a documented Addison disease diagnosis before assigning E27.1.