ICD-10 Code D89.832 – Cytokine release syndrome, grade 2 (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D89.832 – Cytokine release syndrome, grade 2
What it is
D89.832 identifies cytokine release syndrome, grade 2. Use this code when documentation shows a moderate systemic inflammatory response after immune therapy, with symptoms that are more than mild but not life-threatening.
Clinical signs
Clinical features vary; refer to documentation. Grade 2 CRS commonly includes fever with symptoms such as hypotension not requiring vasopressors, hypoxia needing low-flow oxygen, or other moderate systemic findings.
When to use this code
Use D89.832 when the provider documents cytokine release syndrome and specifies grade 2. This is common in patients receiving CAR T-cell therapy or other immune-based treatments when the reaction is clearly staged. If the grade is not stated, check documentation.
Do not use for
Do not use this code for cytokine release syndrome without a documented grade 2 designation. Do not assign it when the record indicates a different grade or a non-CRS inflammatory reaction.
Coding tip
Verify the provider’s exact CRS grade and link the code to the documented treatment-related reaction, not to nonspecific fever or hypotension alone.