ICD-10 Code D89.1 – Cryoglobulinemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D89.1 – Cryoglobulinemia
What it is
D89.1 identifies cryoglobulinemia, a condition in which abnormal proteins in the blood can precipitate when exposed to cold. Use this code when documentation states cryoglobulinemia or a related cryoglobulin disorder.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include purpura, joint pain, weakness, and signs of vasculitis or organ involvement.
When to use this code
Use D89.1 when the record clearly documents cryoglobulinemia as an established diagnosis. It may appear in notes describing cryoglobulin-related vasculitic disease, systemic manifestations, or hematologic evaluation. If the provider only suspects the condition, code the documented signs and symptoms instead.
Do not use for
Do not use this code for nonspecific cold sensitivity or for abnormal lab results without a diagnosis. Check documentation if the note mentions cryoglobulins only as a test finding.
Coding tip
Confirm whether the provider documented a definitive diagnosis, since isolated cryoglobulin positivity is not enough for D89.1.