ICD-10 Code D89.2 – Hypergammaglobulinemia, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D89.2 – Hypergammaglobulinemia, unspecified
What it is
D89.2 identifies an unspecified increase in gamma globulins, usually reflecting elevated immunoglobulins in the blood. Use it when the record states hypergammaglobulinemia but does not document a specific cause.
Clinical signs
Clinical features vary; refer to documentation. Patients may have laboratory evidence of increased globulins, but the code itself does not require a particular symptom pattern or underlying diagnosis.
When to use this code
Use D89.2 when the provider documents hypergammaglobulinemia without naming a more specific disorder, such as autoimmune disease, chronic infection, or plasma cell condition. It is appropriate for problem lists, assessment notes, or encounter diagnoses when the cause remains unspecified. If the chart identifies a definitive etiology, code that condition instead.
Do not use for
Do not use this code when the elevated globulins are clearly tied to a specific diagnosis that has its own code. Do not use it for generalized abnormal lab results without documented hypergammaglobulinemia.
Coding tip
Query for the underlying cause before assigning D89.2, because specificity may change the final code.