ICD-10 Code D89.83 – Cytokine Release Syndrome (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D89.83 – Cytokine release syndrome
What it is
D89.83 identifies cytokine release syndrome, an inflammatory reaction caused by rapid immune activation. Use it when the record documents this specific syndrome rather than a general inflammatory response.
Clinical signs
Clinical features vary; refer to documentation. Commonly described findings include fever, hypotension, hypoxia, and systemic inflammatory symptoms after immune-based therapy or other triggering events.
When to use this code
Use D89.83 when the clinician clearly documents cytokine release syndrome or CRS. It may appear in records related to immunotherapy, cell therapy, or other immune-triggered reactions. Code the condition as documented and confirm whether additional codes are needed for associated manifestations.
Do not use for
Do not use this code for nonspecific fever, sepsis, or allergic reactions unless cytokine release syndrome is documented. Check documentation if the note only describes an inflammatory or infusion-related event.
Coding tip
Look for the exact term “cytokine release syndrome” or “CRS” in the assessment, not just symptoms.