ICD-10 Code D89.812 – Acute on chronic graft-versus-host disease (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D89.812 – Acute on chronic graft-versus-host disease
What it is
Acute on chronic graft-versus-host disease is a transplant complication where chronic graft-versus-host disease develops acute worsening features. It reflects immune attack from donor cells after an allogeneic stem cell or bone marrow transplant.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include skin, liver, mouth, eye, or gastrointestinal involvement, with new or worsening symptoms superimposed on chronic disease.
When to use this code
Use this code when the provider documents acute on chronic graft-versus-host disease, or clearly states chronic GVHD with an acute flare. You should code it only when the record supports both the chronic condition and the acute worsening.
Check documentation if the note uses vague terms such as “GVHD flare” or “worsening GVHD” without specifying acute on chronic disease. Do not assume this code from transplant history alone.
Do not use for
Do not use this code for acute graft-versus-host disease without chronic disease, or for chronic GVHD without an acute component. Check documentation if the type of GVHD is not clearly stated.
Coding tip
Code the exact GVHD type documented by the provider; if the record does not clearly say acute on chronic, query for clarification.