ICD-10 Code D89.81 – Graft-versus-host disease (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D89.81 – Graft-versus-host disease
What it is
D89.81 identifies graft-versus-host disease, a complication that can occur after an allogeneic transplant when donor immune cells attack the recipient’s tissues. It is documented as acute or chronic when specified.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include skin rash, gastrointestinal symptoms, liver involvement, or other organ manifestations after transplant.
When to use this code
Use D89.81 when the provider documents graft-versus-host disease as a diagnosis or complication of transplant care. Code the condition when it is confirmed in the record, whether current or ongoing. If the note does not clearly identify GVHD, check documentation before assigning the code.
Do not use for
Do not use this code for transplant rejection, nonspecific post-transplant complications, or donor-related issues without graft-versus-host disease. Check documentation if the record only states “post-transplant reaction.”
Coding tip
Confirm whether the provider documents acute, chronic, or unspecified GVHD, and code any associated transplant complication only when supported by the record.