ICD-10 Code C94.4 – Acute panmyelosis with myelofibrosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C94.4 – Acute panmyelosis with myelofibrosis
What it is
C94.4 identifies acute panmyelosis with myelofibrosis, a rare acute myeloid neoplasm affecting multiple marrow cell lines. It is used when documentation specifically names this diagnosis.
Clinical signs
Clinical features vary; refer to documentation. Standard references describe marrow failure findings, circulating immature cells, and evidence of myelofibrosis on evaluation.
When to use this code
Use C94.4 when the provider documents acute panmyelosis with myelofibrosis as the confirmed diagnosis. It may appear in pathology, hematology, or oncology records describing a primary marrow malignancy. If the note only says acute leukemia or myelofibrosis without this exact entity, check documentation before assigning the code.
Do not use for
Do not use this code for other acute leukemias, chronic myeloproliferative disorders, or myelofibrosis without acute panmyelosis. If the diagnosis is uncertain or abbreviated, verify the record first.
Coding tip
Code C94.4 only when the documented diagnosis is explicit; do not infer it from nonspecific leukemia language.