ICD-10 Code C94.22 – Acute megakaryoblastic leukemia, in relapse (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C94.22 – Acute megakaryoblastic leukemia, in relapse
What it is
This code identifies acute megakaryoblastic leukemia that has returned after a period of remission. Use it when documentation states the disease is back, recurrent, or relapsed.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings may include anemia, bleeding tendency, bruising, infections, or abnormal blood counts consistent with acute leukemia.
When to use this code
Use C94.22 when the provider documents acute megakaryoblastic leukemia as relapsed, recurrent, or in relapse. This applies when the current encounter is for active disease after prior remission. If the record only says “history of leukemia” or does not specify relapse, check documentation.
Do not use for
Do not use this code for newly diagnosed acute megakaryoblastic leukemia or for leukemia in remission. If the chart does not clearly state relapse, do not assume recurrence.
Coding tip
Confirm that the note explicitly links the leukemia to relapse, because recurrence status changes code selection.